Dear Jayashankar,

How refreshing it is to hear someone question how things work. Bill and Mark are beginning to show you the way. You are ready to roll up your sleeves and study the subject. This list of apparently solved problems hides a wonderland of studies and hard work (some of it based on Bill's and Mark's perspiration, and that of many others) that depend on fundamentals in physics, biology, cryogenics, computer science, and on and on.

Take each one and start asking questions. If your curiosity lasts, you have a chance of making some nice advances in the field.

Bob


On Sat, 20 Sep 2008, Jayashankar wrote:

Dear friends and crystallographers,

During One of my lab meeting ,

I told twinning in crystals are ok, because ccp4's recent releases just need 
the keyword TWIN to
solve them,

As a new generation research student, I am now confused, is that I need to 
learn and understand all
programs(so many...but research does not  mean relaying on them) 
to solve my crystallographic problems(is that all)....
if you see all the queries in ccp4BB is just about undocumented or 
misunderstood program oriented
questions.

is  that all i have to learn in crystallography in future.
Still upto what limitations we are now in crystallography.
this is my very naive and prime question.

1.Phase problem
2.twin problem
3.solving intrinsically disordered proteins
4.hetro multimeric proteins
5.high order oligomers
6.cryo crystallography
7.automation in high through put crystallography
8.radiation damage
9.kinetic crystallography
10. crystal growth research (antigravity, pressure )
11.stereo graphics

if i am right all the above has been studied (....what we are not clear still 
about them),

I need an answer to motivate me in doing my research in Crystallography.

S.Jayashankar
(A confused new generation research student)
Research Student
Institute for Biophysical Chemistry
Hannover Medical School
Germany.



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