Hi,
In addition to the excellend comments posted already, I would like to venture an opinion regarding learning, technology, and associated matters. Do not make the problem fit the techniques you know - instead try to make sure that you know (or know where to learn) enough techniques to solve the problem at hand. This rather simple principle appears to be frequently forgotten or ignored - sometimes with humorous results. As a corollary, I would like to also mention that the relatively huge area of science that is often referred to as 'macromolecular crystallography' can be approached as a basic area of science in itself, or it may be viewed as a set of sophisticated technologies suitable for answering complex questions in structural & basic biology, drug design, protein engineering, etc. etc. Regardless of what you personally decide to do, try to view it as both basic and applied science - this approach pays off later. Artem P.S. twinned crystals still suck. _____ From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of Jayashankar Sent: Saturday, September 20, 2008 5:18 PM To: [email protected] Subject: [ccp4bb] Crystallogrphy today Dear friends and crystallographers, During One of my lab meeting , I told twinning in crystals are ok, because ccp4's recent releases just need the keyword TWIN to solve them, As a new generation research student, I am now confused, is that I need to learn and understand all programs(so many...but research does not mean relaying on them) to solve my crystallographic problems(is that all).... if you see all the queries in ccp4BB is just about undocumented or misunderstood program oriented questions. is that all i have to learn in crystallography in future. Still upto what limitations we are now in crystallography. this is my very naive and prime question. 1.Phase problem 2.twin problem 3.solving intrinsically disordered proteins 4.hetro multimeric proteins 5.high order oligomers 6.cryo crystallography 7.automation in high through put crystallography 8.radiation damage 9.kinetic crystallography 10. crystal growth research (antigravity, pressure ) 11.stereo graphics if i am right all the above has been studied (....what we are not clear still about them), I need an answer to motivate me in doing my research in Crystallography. S.Jayashankar (A confused new generation research student) Research Student Institute for Biophysical Chemistry Hannover Medical School Germany.
