Dear All,

I'm trying to decide the spacegroup between P21 and C2 and in need of
your help.
I have a data with the following possible cells:
P21: 41.8500  119.4800   93.2600   90.0000  102.8880   90.0000
C2: 181.8000   41.8400  119.5300   90.0000   90.0820   90.0000

The data is twinned (C2221 is always suggested by different programs without considering twinning). Therefore twin refinement is carried on in
Phenix.refine, with twin law "h,-k,-h-l" for P21 and  "h,-k,-l" for
C2.  Both space groups give a reasonable but not so different R-free
close to 23% for a 2.3 angstrom data, and the resulted map is also OK
in both cases.  As it is with higher symmetry, maybe I should go with
C2. But there could be something I missed here, i.e. a pseudosymmetry
operator taken as crystallographic symmetry?  Any suggestions or
comments are highly appreciated!

Thanks,

Hua

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