Applications are invited for the following positions as
* Ph.D.
student (female/male)*
and
* Postdoctoral
fellow (female/male)*
* for Structural
Biology of Infections *
*(Protein Crystallography / Drug Design / Synthetic Organic Chemistry).*
* *
The positions are available at the Institute of Biochemistry (Director:
Prof. Dr. Rolf Hilgenfeld), University of Lübeck, Germany.
*1. **Ph.D. studentship, reference number 434/08*
*Research area: Investigation of interactions between proteins of
Chlamydia and host cell factors *
Methodology: Crystallography/Molecular Biology/Microbiology
Duration: initially limited to two years, extension possible
*2. **Two Ph.D. studentships or one postdoctoral fellowship, reference
number 435/08*
*Research area: Investigation of interactions between Influenza
viruses and host cell proteins *
Methodology: Crystallography/Molecular Biology
Duration: initially limited to two years, extension possible
*3. Ph.D. studentship, reference number 436/08*
Research area: Flaviviral enzymes as targets for antiviral therapies
Methodology: Crystallography/Molecular Biology/Drug Design
Duration: initially limited up to two years, extension possible
*4. Two Ph.D. studentships or one postdoctoral fellow, reference number
437/08*
Research area: Enterovirus proteases as targets for antiviral
therapies
Methodology: Synthetic organic chemistry /Crystallography
Duration: initially limited up to two years, extension possible
*5. **Ph.D. studentship, reference number 438/08*
*Research area: Host cell proteins as targets for anti-HIV therapy*
Methodology: Crystallography/Molecular Biology
Duration: initially limited to two years, extension possible
The Institute of Biochemistry (www.biochem.uni-luebeck.de
<http://www.biochem.uni-luebeck.de>) possesses a long-standing
reputation for research on the molecular basis of intracellular
infections by RNA viruses (particularly coronaviruses including the SARS
virus), bacteria and protozoa, with the objective to design and develop
new antiinfective drugs (e.g. /EMBO J./ *21*, 3213 (2002), /Science/
*300*, 1763 (2003), /PNAS/ *100*, 13190 (2003), /Cell/ *117*, 57 (2004),
/JMB/ *354*, 25 (2005), /JBC/ *281*, 25425 (2006), /Chem Biol/ *15*, 597
(2008), /JMB/ *383*, 1081(2008)).
The announced positions should push forward the research in the field of
structural biology of infections, particularly the characterization of
protein-protein interactions between viral or bacterial virulence
factors and host cell components. A further objective consists in the
structural characterization of the binding properties of inhibitors to
target proteins. Based on X-ray structures of the corresponding
complexes, such lead compounds are designed and synthesized at the
Institute of Biochemistry. The successful candidates will gain profound
experience in a broad variety of experimental and computational
techniques. Various techniques required for the preclinical development
of antiinfective drugs such as proteomics, crystallization, X-ray
structure determination as well as chemical synthesis of inhibitors are
available in-house. The institute is well equipped with crystallization
facilities such as crystallization robots and imaging systems. We also
operate an outstation at DESY (Hamburg) with direct access to
synchrotron radiation.
The positions will be paid according to E13 on the TV-L scale in case
all contractual prerequisites are fulfilled. A final grading remains
reserved. The working schedule will be in accordance to § 6 TV-L.
The university seeks to achieve a balance between female and male
coworkers and advocates the employment of disabled individuals.
Accordingly, applications of female or disabled candidates with
equivalent qualification will be preferably considered.
The announcement addresses particularly successful candidates
(female/male) holding a degree in biochemistry, chemistry, and pharmacy.
Further information can be obtained from the director of the institute,
Prof. Dr. Rolf Hilgenfeld ([email protected]
<mailto:[email protected]>).
Applications in written form are expected until January 12, 2009 with
indication of the corresponding reference number to: **
*Universität zu Lübeck*
*-Der Präsident-*
*- Dezernat Personal -*
*Ratzeburger Allee 160*
*23538 Lübeck*
--
Dr. Holger Steuber
Professor (W1) for Structure-based Drug Design
Institute of Biochemistry
University of Luebeck
Ratzeburger Allee 160
23538 Luebeck
Germany
Phone : +49-451-500-4065
Fax : +49-451-500-4068
E-mail : [email protected]
