A position is available for a highly motivated doctoral or post-
doctoral researcher at the Laboratory for Structural Neurobiology at
the KULeuven, Belgium. The research in our laboratory is currently
focused on the structural determination of several classes of
prokaryotic and eukaryotic homologs of ligand- and voltage-gated ion
channels. At this point we have several ongoing projects at various
stages, ranging from promising expression screens to in-house
diffracting crystals. We share part of our equipment with Dr. Sergei
Strelkov’s Biocrystallography group, which is fully equipped with an X-
ray diffractometer (Rigaku/Mar), computer cluster and crystallization
robotics. Both groups have frequent access to several beamlines at
European synchrotron facilities.
The successful candidate must be strongly motivated and should possess
excellent written and oral communication skills. Experience in cDNA
cloning, cell culture and protein purification techniques are
required. Prior experience with membrane protein crystallography or a
background in electrophysiology would be a major advantage.
To apply for this position please send curriculum vitae, a brief
statement describing technical expertise, future research interests
and the names of at least two references to: chris.ulens at
med.kuleuven.be
The position is open immediately. Applications will be accepted until
the position is filled.
Selected publications of Chris Ulens’s research are:
- Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping
G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ.
AChBP-targeted alpha-conotoxin correlates distinct binding
orientations with nAChR subtype selectivity. EMBO J. 2007 Aug
22;26(16):3858-67.
- Ulens C, Hogg RC, Celie PH, Bertrand D, Tsetlin V, Smit AB, Sixma
TK. Structural determinants of selective alpha-conotoxin binding to a
nicotinic acetylcholine receptor homolog AChBP. Proc Natl Acad Sci U S
A. 2006 Mar 7;103(10):3615-20.
- Ulens C, Siegelbaum SA. Regulation of hyperpolarization-activated
HCN channels by cAMP through a gating switch in binding domain
symmetry. Neuron. 2003 Dec 4;40(5):959-70.
- Ulens C, Tytgat J. Functional heteromerization of HCN1 and HCN2
pacemaker channels. J Biol Chem. 2001 Mar 2;276(9):6069-72.
Most importantly (!!) - according to Wikipedia <snip> Belgium is well
known for its cuisine. Many highly ranked restaurants can be found in
the high-impact gastronomic guides, such as the Michelin Guide.
Belgian food is, like the country itself, a mix of Germanic and Latin
influences. Belgians have a reputation for loving waffles and French
fries; contrary to the name of the latter, both dishes originated in
Belgium. The national dishes are steak-frites with salad, and moules-
frites (mussels with frites). Brands of Belgian chocolate and
pralines, like Callebaut, Côte d’Or, Neuhaus, Leonidas, Guylian and
Godiva, are world renowned and widely sold. Belgium produces over 500
varieties of beer. The biggest brewer in the world by volume is InBev
based in Belgium.</snip>
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