> I am annoyed at the fact that Refmac doesn't seem to have much respect 
> for the electron density map 

Other people are much better qualified than me to point this out, but 
maximum likelihood methods have the utmost respect for your _data_ (and 
especially their standard deviations). What you think you see in the map 
is not what your data really 'say'.



-- 


             Dr Nicholas M. Glykos, Department of Molecular 
         Biology and Genetics, Democritus University of Thrace,
   University Campus, 68100 Alexandroupolis, Greece, Fax +302551030613
      Tel ++302551030620 (77620),  http://www.mbg.duth.gr/~glykos/

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