> I am annoyed at the fact that Refmac doesn't seem to have much respect > for the electron density map
Other people are much better qualified than me to point this out, but maximum likelihood methods have the utmost respect for your _data_ (and especially their standard deviations). What you think you see in the map is not what your data really 'say'. -- Dr Nicholas M. Glykos, Department of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, 68100 Alexandroupolis, Greece, Fax +302551030613 Tel ++302551030620 (77620), http://www.mbg.duth.gr/~glykos/