Zenobia Therapeutics is now providing a fragment screening library suitable for use with protein crystallography.
The library contains a diverse set 352 small molecule compounds with a mean molecular weight of 155 Da. The chemical compound types (typically, simple decorated rings) are suitable for efficiently probing protein sites to determine binding substructures for lead discovery. The compounds in the library are pre-plated so as to provide 100uL of each compound at 200mM concentration. All compounds have been tested to ensure adequate solubility in DMSO. To simplify the experimental design and interpretation of fragment screening experiments with mixtures the compounds are organized in to shape-diverse groups and 3D structure models of all compounds are provided. For additional information on Zenobia Therapeutics, Inc., contact Dr. Vicki Nienaber at [email protected] or visit www.zenobiatherapeutics.com. For additional information on Zenobia's fragment library, contact Dr. John Badger at [email protected]. John Badger, Director of Structural Biology, Zenobia Therapeutics http://www.zenobiatherapeutics.com/
