Postdoctoral Training Fellow - Structural Biology of Hsp90 Complexes
Section of Structural Biology, ICR
Chester Beatty Laboratories
Chelsea, London, UK
A Wellcome Trust-funded Postdoctoral position is available from 1st
October 2009 in the laboratory of Professor Laurence Pearl FRS, in the
Section of Structural Biology, to study the structural basis for
regulation and activation of 'client' proteins by the Hsp90 molecular
chaperone system. The Postdoc will be responsible for expression,
purification, crystallization and structural analysis of protein
complexes involving the Hsp90 molecular chaperone, its co-chaperones and
client proteins that depend on Hsp90 for their biological function.
The Institute of Cancer Research (a College of the University of London)
is a world-class cancer research organization receiving the highest
rating in the 2008 RAE. In partnership with The Royal Marsden NHS
Foundation Trust, we form the largest comprehensive cancer centre in
Europe, dedicated to research that extends from world leading basic
science in epidemiology, genetics and structural and molecular biology,
through drug discovery and development, to cancer diagnosis and patient
treatment.
The Section of Structural Biology at ICR is exceptionally well equipped
for all aspects of modern structural biology, with state-of-the-art
laboratories for molecular biology, recombinant expression in bacterial
and eukaryotic systems, biochemistry, X-ray crystallography and electron
microscopy. Excellent synchrotron access (~ 2 days/month) is available
through rolling beam allocation programmes at Diamond and ESRF.
Applicants must have a PhD, and experience in recombinant expression,
protein purification, crystallisation and X-ray crystallography.
Information on our previous work in this field can be found by searching
PubMed and via the ICR Website http://www.icr.ac.uk/index.shtml
The starting salary for the position will be in the range £26,966 to
£35,518 p.a. inclusive (based on previous post-doctoral experience) and
the post is offered initially on a fixed term contract of up to 2 years.
Informal enquiries can be made to Professor Laurence Pearl
([email protected]). Please note -- this address is for enquiries
ONLY and CVs must be submitted in line with the instructions below.
To apply, please send two copies of your CV, including the names and
addresses of two referees to the HR Office, The Institute of Cancer
Research, 123 Old Brompton Road, London SW7 3RP, quoting reference C
219 For a job description and person specification please visit our
website at: www.icr.ac.uk/jobs.html. Alternatively, you may call our 24
hr recruitment line on 020 7153 5475.
Closing date: 8 May 2009
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Laurence H. Pearl PhD FMedSci FRS
Professor of Protein Crystallography and Section Chairman
Section of Structural Biology, Institute of Cancer Research
Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB
Phone +44-(0)20 7153 5422 : Secretary 5443 : FAX 5457
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"Live Simply and do Serious Things .. "
- Dorothy Crowfoot Hodgkin
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The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company
Limited by Guarantee, Registered in England under Company No. 534147 with its
Registered Office at 123 Old Brompton Road, London SW7 3RP.
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