[ccp4bb] negative difference density in protein interiors

[Laurie Betts]

Specifically, hemoglobin, in original PHASER (unrefined) solution  
DELFWT an continuing to show up in refined
DELFWT coefficients.  But I have seen it in other cases too.
What does it mean?

Thanks


Laurie Betts
University of Pittsburgh
X-ray Crystallography Facility Manager
Department of Structural Biology
3501 Fifth Avenue,
Pittsburgh, PA 15260
412-383-5839
lab...@pitt.edu