Dear BB,
I'm refining a structure which presents a big hydrophobic cavity where a
strong residual difference negative density can be seen. I presume that
this is an effect of not having a proper solvent mask determined and I
was wondering if there is a way to provide a better mask description to
REFMAC. The resolution of the data is 1.6 A and I have already tried
changing from simple to Babinet scaling, without any improvement. Any
advice/suggestion would be very welcome.
Many thanks,
Ana-Maria
--
Ana-Maria Goncalves
Macromolecular Crystallography Group
European Synchrotron Radiation Facility
B.P. 220, 6 rue Jules Horowitz
F-38043 GRENOBLE CEDEX
FRANCE
Tel: +33 (0) 4.76.88.19.12
Fax: +33 (0) 4.76.88.29.04
