Some years ago, I produced a short computer-animated video (complete
with music and narration) for Jon Clardy's group on chorismate
mutase. The e. coli and b. subtilis forms of chorismate mutase
catalyze the same claisen rearrangement but have completely different
folds and hydrogen bond networks ... convergent evolution I presume.
I have a HUGE Quicktime version of the movie digitized from the
original master tape, but have not taken the time to burn it to DVD
yet. I suppose I should put all my videos on youtube someday. (Also
available as VHS tape). Let me know if you would like a version for
teaching purposes and I'll see if I can burn a copy.
Richard
On Jun 22, 2009, at 6:55 AM, Justin Lecher wrote:
Hello everxone,
I am looking for an example of two proteins where the primary sequence
does not show any significant similarities, but which have the same
function due their structure? I want to use it to demonstrate that
function could not always deduced from sequence alignments, but from
structure alignments.
Does anyone could give me some good examples?
Thanks Justin
--
Justin Lecher
Institute for Neuroscience and Biophysics
ISB3 - structural biochemistry
Research Centre Juelich GmbH,
52425 Juelich,Germany
phone: +49 2461 61 5385
