Re: [ccp4bb] multi-domain protein with identical tertiary structure

[Roger Rowlett]

The same is true for Porphyridium purpureum beta-CA and Halothiobacillus neapolitanus beta-CA. Both are composed of pseudodimers composed of two structurally homologous domains. In the case of H. neapolitanus, the domains have very little sequence homology, and one domain has lost its active site, but not the overall fold. I suspect there are many examples of this kind of multidomain chain homology that probably originates from gene duplication events. Cheers, Roger Rowlett Phil Jeffrey wrote: The cadmium-utilizing marine diatom carbonic anhydrase (CA) protein has three consecutive CA domains that have very similar structures but non-identical sequences. See: Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM. Nature. 2008 Mar 6;452(7183):56-61. Shankar Prasad Kanaujia wrote: Dear CCP4 users, Is there any multi-domain protein (with at least two domains) which has identical tertiary structure of each domain ? Thanking you. -regards shankar