Dear Wei, The unit-cell dimensions are certainly not excessive, we recently published the 2.8A 27kDa uridylate kinase structure from B. anthracis whose crystals were P6122, a=b=87, c=384 with three UK in the ASU.
As you are apparently not seeing any self rotation peaks, have you looked for a translation in the native Patterson? That might explain difficulties in solving by MR. Good luck, Robert -- Dr. Robert Esnouf, University Research Lecturer, Head of Bioinformatics and IT, The Division of Structural Biology and The Oxford Protein Production Facility, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK Emails: [email protected] Tel: (+44) - 1865 - 287783 and [email protected] Fax: (+44) - 1865 - 287547
