*Project Research Scientist- Synthetic Biology / Structural Genomics*
The Synthetic Biology / Structural Genomics Program at the DOE Joint
Genome Institute (JGI) in Walnut Creek, CA has an exciting scientific
research opportunity available. Will serve as a Project Scientist and
design and implement experiments to study the assembly and the
structural basis function of carboxysomes, related bacterial
microcompartments and other proteins related to the Department of
Energy's (DOE) bioenergy related missions using single crystal X-ray
diffraction techniques with synchrotron radiation. Will develop and
lead new projects and research methods within the program and prepare
funding proposals and research publications. Research will be conducted
at the DOE Joint Genome Institute with access to the University of
California, and the Lawrence Berkeley Laboratory and offers a rich and
dynamic scholarly environment with the latest in genomics,
bioinformatics and structural biology. Will report to the Synthetic
Biology / Structural Genomics Program Lead.
*Specific Job Duties*
/Essential-/
- Design and carry out experiments (from protein preparation to
structure analysis and manuscript preparation) aimed at elucidating the
structural basis of bacterial microcompartment function.
- Design and carry out experiments to engineer microcompartments or
microcompartment biomemetic devices for new biological applications,
including enhancing carbon capture or biofuel production.
- Conduct X-ray crystallographic structure determination and structure
analysis of component proteins of bacterial microcompartments.
- Coordinate structural analysis (x-ray crystallography and small angle
x-ray scattering) of proteins for the Synthetic Biology and Structural
Genomics Program.
- Evaluate and implement appropriate tools for structural studies.
- Troubleshoot all stages of experimental process from protein
preparation through structure analysis.
- Interface with collaborators, JGI staff, management, and sponsors at
other national laboratories.
- Summarize research results and publish in peer reviewed journals;
contribute to scientific research papers and reports.
- Develop and lead new projects in accordance with the overall aim of
the Synthetic Biology and Structural Genomics programs.
- Prepare funding applications and proposals.
- Lead, mentor and train undergraduates, graduate students, technical
staff and other group members as necessary.
/Marginal-/
- Attend and present technical status reports at group meetings.
- Keep an accurate and detailed laboratory notebook.
*Key Success Factors*
/Essential-/
- PhD in Biochemistry, Biophysics, or a closely related field.
- Skill in all phases of X-ray structure determination including: data
processing, phase determination and improvement, model building, protein
structure refinement and interpretation.
- Experience in overexpression and purification of protein.
- Demonstrated ability to conduct and perform collaborative research and
effectively interact with a broad range of colleagues with tact and
diplomacy.
- Demonstrated ability to independently carry out creative research with
a proven record of publications and achievement.
- Effective problem-solving and decision-making skills with the ability
to troubleshoot experimental processes and provide analysis.
- Excellent organizational, analytical, and record-keeping skills with
the ability organize and present technical reports to collaborators, JGI
staff, management, and sponsors.
- Demonstrated ability to accurately and eloquently represent and
promote scientific projects to audiences of diverse technical backgrounds.
- Effective interpersonal skills with experience establishing effective
collaborations and interacting with members of the scientific,
instrumentation and informatics communities.
- Excellent written communication skills with demonstrated experience
preparing funding proposals and research publications.
- Working knowledge of bioinformatics tools.
/Marginal-/
- Experience providing technical training and the ability to mentor
undergraduates, graduate students and technical staff.
- Experience in high throughput approaches to genetic engineering and
imaging.
See
http://jobs.lbl.gov/LBNLCareers/details.asp?jid=23538&p=1
for applications details
--
Cheryl A. Kerfeld Ph.D.
Head,Structural Genomics & Education Programs
DOE Joint Genome Institute
2800 Mitchell Drive
Walnut Creek, CA 94598//
Adjunct Professor
Dept. of Plant and Microbial Biology
University of California, Berkeley
Phone: (925) 296-5691
FAX: (925) 296 5752
[email protected]
