Hello , I have written an application that makes it easy to design and calculate protein crystallization optimization screens for 24 , 96 and 384 well plates .
Starting with your stock solutions you can create any screening grid using many gridding operations for eg. gradient along X , gradient along Y , constant value , gradient as list , buffer pH gradient etc The application outputs the summary of the screen created as a PDF file with reagents volumes and concentrations. Although I wrote the application to create dispense lists for a formulatrix liquid handling robot which we have in the lab, I am hoping it will be useful to others to quickly design screens and calculate pipetting volumes for manual screen preparation. You can download a binary for Linux , Mac and Windows from http://www.code-itch.com/gridzilla There is also a screencast video that hopefully tells you how the app works at : http://code-itch.com/gridzilla/GridZillaScreencast.swf The source code is available on the site and also on my github acount ( http://github.com/harijay). It can be easily adapted to support other liquid handling input formats. Please let me know if you find the app useful . Feedback , suggestions etc are welcome. Thanks Hari Jayaram
