Two Postdoctoral Research Associates - BR411
Department of Biochemistry & Sir William Dunn School of
Pathology
The Notch pathway is a universally conserved signal transduction
system
in metazoan organisms which plays a crucial role in many
biological
processes, including cell fate determination during development,
cell
proliferation, apoptosis and angiogenesis. Its importance for
human
biology is underscored by a number of diseases resulting from
its
malfunction. Despite extensive analysis of the downstream
consequences
of Notch pathway activation, very little is known at the atomic
level
about the extracellular recognition event between Notch receptor
and
ligand that forms the basis of the signal.
We have solved the first crystal structure of a key Notch
(N-1)-binding
region of human Jagged-1(J-1) and shown through mutagenesis and
in vitro
and in vivo functional assays that a conserved face of J-1
participates
in both cis- and trans-regulatory interactions with N-1. (Cordle
and
Johnson et al, NSMB, 2008) We now wish to investigate the
structural
basis of these interactions with the J-1/Serrate class of
ligands.
We are seeking to appoint two postdoctoral research associates
to join
an interdisciplinary project led by Professor Penny Handford
(Department
of Biochemistry), with Professor Susan Lea (Sir William Dunn
School of
Pathology) and Dr Martin Baron (University of Manchester). One
post will
be based in the Department of Biochemistry and the other in the
Sir
William Dunn School of Pathology. The postholders will be
expected to
establish protocols/procedures and optimisation of systems,
assist with
the design and implementation of experiments and interpret and
present
data for publication
The posts are funded by Wellcome Trust for up to 3 years in the
first
instance.
further particulars available:
http://www.path.ox.ac.uk/about/Vacancies/pdfs/BR411FP
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Prof. Susan M. Lea
Professor of Chemical Pathology Tutor for Graduates
Sir William Dunn School of Pathology Tutorial Fellow Biochemistry
Oxford OX1 3RE UK Brasenose College
tel: +44 1865 275181 Oxford OX1 4AJ
tel: +44 1865 275385 http://users.path.ox.ac.uk/%7Eslea/
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