Postdoctoral/Research Faculty Positions in Structural Biology
Structural Biology of Large Modular Proteins and Protein Complexes
Laboratory of Walter J. Chazin
(1) Regulation of human cardiac Na+ channels and origin of cardiac
arrhythmias
(2) Multi-protein DNA replication, damage response and repair machinery
These project involve complimentary application of structural biology
techniques including NMR, X-ray scattering, X-ray crystallography and
computational modeling. Both research programs incorporate multi-
disciplinary biological and medical studies and routinely produce
publications in a range of high profile journals. Project 1 is
directed to understanding the structural basis for calcium dependent
regulation of gating of the human cardiac sodium channel NaV1.5, and
the origin of cardiac arrhythmias in patients with mutations in the
regulatory apparatus. Project 2 involves studies of the structure and
dynamics of large multi-domain proteins (e.g. replication protein A,
DNA primase, XPC) and protein and DNA complexes within DNA
replication, damage response and repair machines. The Vanderbilt
Center for Structural Biology has outstanding instrumentation in all
areas, including membership in LS-CAT, a close association with the
SIBYLS beamline at ALS, and NMR spectrometers equipped with cryoprobes
operating at 800, 600 and 500 MHz as well as a soon to be installed
900. Applicants are expected to work well with graduate students and
will be encouraged to develop their leadership potential. Send CV and
a reference list to: [email protected].
Vanderbilt University is an equal opportunity employer.
