Hi Armando,
high R-factor at low resolution is likely to be due to poor bulk solvent
model. Some relevant reading:
Jiang, J.-S. & Brunger, A. T. (1994). J. Mol. Biol. 243, 100-115.
"Protein hydration observed by X-ray diffraction. Solvation properties
of penicillopepsin and neuraminidase crystal structures."
A. Fokine & A. Urzhumtsev. Acta Cryst. (2002). D58, 1387-1392. "Flat
bulk-solvent model: obtaining optimal parameters"
P.V. Afonine, R.W. Grosse-Kunstleve & P.D. Adams. Acta Cryst. (2005).
D61, 850-855. "A robust bulk-solvent correction and anisotropic scaling
procedure"
Pavel.
On 10/16/09 7:55 AM, Armando Albert de la Cruz wrote:
What does it mean having the R factors a high resolution lower than at
low resolution?. Could be related to the fact my model is incomplete?
Armando
