Dear colleagues,
I am seeking a person to work on crystallographic structure
determination of proteins involved
in immune resistance in H. pylori. Please see the advertisement below:
RESEARCH ASSOCIATE (REF: 2989)
SCHOOL OF BIOMEDICAL, BIOMOLECULAR AND CHEMICAL SCIENCES
Structural Biology of Molecular Targets from Helicobacter pylori
· 21 month appointment
· Salary range: Level A $53,542 - $72,537 p.a. - minimum
starting salary for appointee with PhD will be $70,058 p.a.
· Closing date: Friday, 19 February 2010
The School is undertaking research aimed at elucidating the structural
and functional mechanisms of molecular targets from Helicobacter
pylori, involved in immune evasion by the organism. The project is
highly cross disciplinary in nature involving crystallographic studies
carried out in the Vrielink Laboratory, organic chemistry synthesis
and inhibitor design in the Stubbs Laboratory and in vivo functional
studies in the group of Nobel Laureate Professor Barry Marshall. The
overarching aim of this project is to design inhibitors of key target
enzymes that can be used as novel therapeutic agents to treat H.pylori
infections.
A postdoctoral position is available to pursue crystallographic
studies of the target proteins. The position will involve developing
protein expression and purification protocols followed by downstream
crystallographic studies. Applicants must have a PhD or equivalent in
Biochemistry or a related discipline and with experience at
macromolecular crystallography. A strong background in molecular
biology, protein expression and purification would be highly
advantageous. The appointee will carry out research in the Vrielink
laboratory but will also be part of a multidisciplinary team within
the School of Biomedical, Biomolecular and Chemical Sciences involving
chemists and microbiologists with outstanding expertise at the study
of H.pylori. As such this position offers excellent opportunities to
interact across multiple disciplines and hence extend research
expertise and career development.
The Structural Biology Laboratory at the University has outstanding
facilities for protein expression and purification as well as in-house
X-ray facilities including a rotating anode generator and two MAR
Imaging plate detectors. Cyrstallization robots are also available or
crystallization experiments. High resolution X-ray data collection
will be carried out at the Australian Synchrotron.
Perth is a thriving and vibrant city, which lies along the Indian
Ocean and benefits from outstanding natural beauty and many
opportunities for outdoor activities. Benefits include superannuation
and salary packaging opportunities. Some assistance with relocation
expenses may be negotiated.
For further information regarding the position please contact Alice
Vrielink by email [email protected].
* PLEASE NOTE: The University will be closed from Friday 25 December
2009 until Tuesday 5 January 2010.
APPLICATION DETAILS: For copies of the position description please
access the website http://jobs.uwa.edu.au/. Written applications
quoting the reference number, personal contact details, qualifications
and experience, along with contact details of three referees should be
sent to Director, Human Resources, The University of Western
Australia, M350, 35 Stirling Highway, Crawley WA 6009 or emailed to [email protected]
by the closing date.
******************************************************************************************************************
Alice Vrielink
Professor of Structural Biology
School of Biomedical Biomolecular and Chemical Sciences
M310
University of Western Australia
35 Stirling Highway
Crawley, WA, 6009
Australia
Email: [email protected]
Phone: +61 08 6488 3162
Fax: +61 08 6488 1005
Webpage: http://crystal.bcs.uwa.edu.au/px/alice/
Proper education is not inculcation. Apart from developing skills and
imparting a core
of indispensable information, education is a process of widening
experience, of fostering
a spirit of inquiry, and thereby of creating the basis for disciplined
judgement" M. I. Finley
******************************************************************************************************************
