POST-DOCTORAL POSITION AVAILABLE at Structural Bioinformatics
Laboratory, Abo Akademi University (Turku, Finland)
http://web.abo.fi/fak/mnf/bkf/research/sbl/
Project: Structural basis for ligand recognition by copper amine oxidases
The project focuses on structural and functional studies of human
vascular adhesion protein-1 (hAOC3), which belongs to the
semicarbazide-sensitive amine oxidases/copper containing amine
oxidases (SSAOs/CAOs E.C. 1.4.3.6). hAOC3 is involved in the leukocyte
trafficking at the sites of inflammation and in glucose uptake. hAOC3
is a target for drug discovery and its roles in inflammatory
conditions are relatively well studied but very little is known about
its physiological substrates and interactions at molecular level. The
aim of the project is to find out the structural determinants for the
unique substrate specificity and physiological interactions of hAOC3.
Required qualifications:
Applicants are expected to have:
- a PhD degree or shortly receive one
- a good knowledge of protein structure
-experience in protein expression, purification, crystallization, data
collection and structural analysis of macromolecules
Experience in structural bioinformatics is of advantage (sequence
alignments, modelling, phylogenetics, and ligand docking). Candidates
do not need to fulfil all qualifications but experience in some of the
above listed areas is essential. Since the project is done in
collaboration with a PhD student and several external collaborators
the applicant should enjoy working in a collaborative environment.
Duration: 4-years (funded by Academy of Finland)
Application:
Respond with a brief statement describing expertise and research
interests, a CV, and contact information of one reference (or letter
of recommendation) by e-mail to [email protected]
Review of applications will begin immediately and continue until the
position is filled. Candidates are encouraged to send applications
before 10.1.2010.
Applicants will be evaluated based on qualifications and suitability
for the project.
--
Tiina Salminen, PhD,
Adjunct professor in Structural biochemistry
Senior lecturer, Biosciences
Department of Biochemistry and Pharmacy
Abo Akademi University
Tykistökatu 6A
FIN-20520 Turku
Finland
