Dear all,
See below a post-doc position available at the Institute of cancer
Research posted on behalf of my colleague Bissan Al-Lazikani which
might be interesting for someone with a structural background. Please
don't reply to me.
Rob van Montfort
The Institute of Cancer Research (a college of the University of
London) is a world-class cancer research organisation with HEFCE RAE
ratings of international excellence across all of its research
programmes, including cancer drug discovery and development. In
partnership with The Royal Marsden NHS Foundation Trust, we form the
largest comprehensive cancer centre in Europe, dedicated to research
that extends from epidemiology, genetics and molecular biology,
through drug discovery and development, to cancer diagnosis and
patient treatment.
Cancer Therapeutics is a multidisciplinary 'bench to bedside' centre,
comprising around 160 staff dedicated to the discovery and development
of novel therapeutics for the treatment of cancer. Our exciting goal
is to discover high quality drug candidates for validated biological
targets and to progress these candidates to clinical trial. All the
scientific disciplines are in place to make this possible including
medicinal chemistry, biology, drug metabolism and clinical
specialists, all of whom focus on new molecular targets emerging from
human genome and ground breaking cell biology research. Drug discovery
is carried out in highly-focused multi-disciplinary project teams
entirely analogous to those in a biotechnology company, with patient
benefit as the primary driver.
This is a postdoctoral position in the new Computational Biology &
Chemogenomics Team within Cancer Therapeutics, whose goal is to
develop and apply novel computational biology and chemogenomic
resources to support drug discovery. Cancer Therapeutics boasts a very
large collection of pharmacological and cancer disease relevant data
as well as access to novel, large scale, internal and external
chemogenomic data resources. These combined, datasets have the
potential to deliver valuable knowledge to guide cancer drug discovery.
The successful candidate will apply their skill in computational
biology and software development to mine heterogeneous biological and
chemical data, develop and apply novel, cancer specific, target
assessment and prioritisation methods, using biological annotation, 3D-
structural information, expression, mutation and interaction network
data as well as chemical data. The candidate will apply these methods
with the aim of identifying novel cancer drug targets, (both
individual and multiple targets within a cancer relevant interaction
network) and suggest suitable chemical tools for pursuing within
Cancer Therapeutics. The candidate will develop experience in a drug
discovery environment, exposure to the drug discovery process, and
knowledge in the emerging chemogenomics field (the merger of
biological and chemical knowledge at large scale), and will also
bolster their programming and data mining skills.
Experience in computational biology, programming, data mining and data
visualisation techniques is essential. Successful applicants will have
ample opportunity to develop additional skills in post. This is an
ideal opportunity for an enthusiastic, committed scientist to make an
important contribution to improved therapies for cancer patients,
while gaining experience and training in drug discovery skills in an
institute with a track record of success. Appointments will be on a
two-year contract in the first instance and salary will be on the
Postdoctoral Training Fellow scale in the range of £29,695-£33,188
p.a. inclusive based on relevance of skills and experience.
To apply please email your CV and covering letter (addressing where
you meet the person specification and incl. the names and addresses of
two referees) to: [email protected], quoting job reference number
B340.
For more details see our website:
http://www.icr.ac.uk/jobs/current_vacancies/14467.shtml
Closing date for applications: 15 January 2010
Dr. Rob van Montfort
Team Leader Structure-Based Drug Design
Sections of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK
Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: [email protected]
The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company
Limited by Guarantee, Registered in England under Company No. 534147 with its
Registered Office at 123 Old Brompton Road, London SW7 3RP.
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