Dear All, Apologies for a non-CCP4question. I have a structure of a dimeric molecule, where the interfaces between monomers is held by a couple of tyrosine residues (per monomer) juxtaposed with each other. The molecule exists as a dimer in solution. Are there ways/programs to show that the interaction between the tyrosine residues is not a consequence of crystal contacts. I guess the fact that the molecule occurs as a dimer in solution strongly suggests so. Also, any directions towards literature showing similar cases would be of great help.
Many thanks in advance -- Amit Sharma Postdoctoral Fellow, Department of Biophysics, Johns Hopkins University, Baltimore, MD21218
