A postdoc position in membrane protein structural biology is available in the Biomolecular Research Laboratory (BMR) at the Paul Scherrer Institute, Switzerland. The successful candidate will work on the production, characterization, crystallization and structure determination of the serotonin receptors in different conformational states by X-ray crystallography. The project is funded by our external industrial partner, Heptares Therapeutics Ltd. The successful candidate will benefit from the BMR high throughput cloning and protein expression platform to speed up the cloning, expression, purification and crystallization steps. The protein crystallography beamlines of the Swiss Light Source (SLS) at PSI also provide excellent conditions for carrying out crystallographic work. Both Xiao-Dan Li and Gebhard Schertler have extensive experience in the structure determination of membrane proteins using X-ray crystallography as well as electron microscopy.
Candidates with a background in biological/chemical sciences and with a thorough knowledge of the basic techniques of molecular biology, biochemistry and biophysics are encouraged to apply. Experience in mammalian protein expression systems, purification, characterization and structure determination of membrane proteins is highly desirable. Being an enthusiastic researcher and a good team player will help to ensure your success in this exciting field of study. The contract will initially be for 2 years with the possibility of a one year extension. Applications including full curriculum vitae and the names of 3 academic referees should be sent to: Xiao-Dan Li, [email protected] and Gebhard Schertler , [email protected].
