Hello, I am solving a structure of an enzyme, which crystallises as a dimer. We have pretty good evidence that this operates as a dimer in vitro, also. We have an inhibitor of this enzyme, which we are keen to visualise by X-ray methods. We seem to have very strong density in which we can model our inhibitor, with good stats and no negative density. However, there is only density in one of the monomers, nothing in the other. The SG is P212121, and although I can postulate why this may have happened (if this is indeed what HAS happened), different solvent channel accessibility etc., I would like to know how common this was and, if possible, some literature regarding this, if the board would be so kind?
Regards, Andrew.
