Have you picked from multiple images and do you have more than 1000 reflections 
to index from?
You might also want to limit the resolution manually to perhaps 3 first.
Before processing your data you should refine your cell by using multiple  
wedges of 10 degrees.
Check out the manual for additional keywords.

Jürgen

-
Jürgen Bosch
Johns Hopkins Bloomberg School of Public Health
Department of Biochemistry & Molecular Biology
Johns Hopkins Malaria Research Institute
615 North Wolfe Street, W8708
Baltimore, MD 21205
Phone: +1-410-614-4742
Lab:      +1-410-614-4894
Fax:      +1-410-955-3655
http://web.mac.com/bosch_lab/

On Jul 20, 2010, at 10:03 PM, Sampath Natarajan wrote:

> 
> Dear All,
> 
> I have the problem in processing the data with imosflm. The data was 
> collected with 2.5A resolution about 300 images.  Auto index found the space 
> group P222 with unit cell a= 40.2; b= 79.2; c= 194.7 and α=b=γ = 90.0. For 
> this cell, the penalty is 7. I feel this penalty is good enough to select the 
> cell based from the list. When I start to refine the cell, the new popup 
> window is opening with some suggestions as below.
> 
> “The index process has failed. It might be worthwhile trying again with”
> 
> 1. A larger or smaller largest cell edge
> 2. Using more or fewer reflections (200-1000 is best)
> 3. Using more and / or different images
> 4. Checking your direct beam position carefully
>  
> Could anyone help me to solve these problems?
> 
> Thanks,
> 
>  Sincerely
> 
> Sampath N
> 

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