Hi all,

I work on a protein that has two know space groups at the same condition. One is P21 with 1 molecule in the ASU (small cell) and the other is P21 with 2 molecules in the ASU (large cell with pseudo-translational symmetry and is a giant pain in the butt to deal with). I was shooting a crystal today and the first image was the large cell, as it is a large crystal and I was feeling lazy so I just translated the crystal in the beam and collected another image and it was the small cell. I looked around but there doesn't seem to be any literature covering this topic.

Is this a common phenomenon or should I be intrigued?

Thanks in advance for the help,

Katherine

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