A Wellcome Trust funded post-doctoral position is available from September in the Astbury Centre for Structural Molecular Biology at the University of Leeds in the laboratories of Dr John Barr and Dr T. Edwards. The successful applicant will study structural and functional aspects of bunyavirus gene expression. We are looking for highly motivated candidates that have a Ph.D. in structural biology with a strong research background in molecular biology and/or virology. The deadline for formal applications is the end of August.
See details below and: http://www.nature.com/naturejobs/science/jobs/153434-Research-Fellow Cheers, Ed ______________ T.Edwards Ph.D. Director, Macromolecular Crystallography Unit Garstang 8.53d Astbury Centre for Structural Molecular Biology University of Leeds, Leeds, LS2 9JT Telephone: 0113 343 3031 http://www.bmb.leeds.ac.uk/staff/tae/ -- Science is simply common sense at its best. ~Thomas Huxley Research Fellow (Fixed-term for 36 months, starting from September 2010) Project Title: Structural and functional analyses of the bunyavirus ribonucleoprotein complex You will study structural and functional aspects of bunyavirus gene expression, in the laboratory of Dr. John Barr. The post is funded by The Wellcome Trust, and will focus on the structural and functional analysis of the nucleocapsid (N) protein of Bunyamwera virus (BUNV), which is a segmented negative stranded RNA virus of the family "Bunyaviridae". The N protein is a major structural component of the virus, which binds the viral genome to form the ribonucleoprotein (RNP), and this association is critical for both RNA synthesis and virus assembly. The project will follow on from our recent crystallization of the BUNV N protein, and will use X-ray crystallography to determine the high-resolution structure of the N protein. This information will then be used to guide an investigation of known N protein functions, assays for which are already established in our laboratories. These assays include: N protein oligomerization, N:RNA interaction, RNP formation, polymerase binding and RNA synthesis activity. A PhD in structural biology is required, together with a strong research background in molecular biology and/or virology. Informal enquiries to Dr. John N. Barr, email [email protected] or Dr. Tom A. Edwards, email [email protected]
