Could you please try refmac 5.6. I think we have fixed this problem. It is 
available from:

www.ysbl.york.ac.uk/refmac/latest_refmac.html

You need to take experimental version (it is now fairly stable)

Regards
Garib

On 6 Sep 2010, at 15:01, Lionel Costenaro wrote:

> Hello, 
> 
> When I run Refmac with the mixed iso/anisotripic B-value option (refi bref 
> MIXED), refmac failed with the error message below.
> My pdb comes from previous refmac runs with anisotropic B values for all 
> atoms (H generated but not written).
> I just removed from the pdb the ANISOU lines for all water molecules.
> 
> Refmac with "refi bref ANIS" (all anisotropic B) works fine (normal 
> termination) with the same input data and pdb - with all ANISOU lines.
> CCP4Interface 2.0.5
> Refmac_5.5.0102
> 
> Any comments, help, fix are welcome.
> 
> Best regards, 
> Lionel
> 
> ******************
>      CGMAT cycle number =      1
>  
> .....
>  Trying gamma equal    0.000000    
>  Not converging with gamma equal    0.000000    
>  Trying gamma equal   5.5000003E-02
>  Not converging with gamma equal   5.5000003E-02
>  Trying gamma equal   0.1155000    
> .....
>  Not converging with gamma equal    2655.967    
>  Trying gamma equal    2921.619    
>  Not converging with gamma equal    2921.619    
>  Trying gamma equal    3213.836    
>  Gamma decreased to    3155.393    
> ***************************************************************************
> * Information from CCP4Interface script
> ***************************************************************************
> The program run with command: /all/programas/ccp4-6.1.2/bin/refmac5 XYZIN 
> "/data/refmac8-coot-0Wiso.pdb" XYZOUT "/tmp/lcocri/21_2_pdb_1.tmp" HKLIN 
> "/data/4_unique1.mtz" HKLOUT "/tmp/lcocri/21_3_mtz_1.tmp" LIBIN 
> "/data/ligand.cif" LIBOUT "/data/21_lib.cif" 
> has failed with error message
> child killed: SIGABRT
> ***************************************************************************
> 
> 
> #CCP4I TERMINATION STATUS 0 child killed: SIGABRT
> #CCP4I TERMINATION TIME 06 sep 2010  15:28:12
> #CCP4I MESSAGE Task failed
> 
> 
> 
> 
> 

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