2 Postdoctoral Research Fellows in Structural Biology of Hsp90 complexes (Ref 041)
Genome Damage and Stability Centre School of Life Sciences University of Sussex, Brighton, U.K. Two Wellcome Trust-funded Postdoctoral positions are available immediately in the laboratory of Professor Laurence Pearl FRS to study the structural basis for client protein recruitment and activation by the Hsp90 molecular chaperone system. The School of Life Sciences is very well equipped for all aspects of modern structural biology, with state-of-the-art laboratories for molecular biology, recombinant expression in bacterial and eukaryotic systems, biochemistry, biophysics and X-ray crystallography. Excellent synchrotron access (~ 2 days/month) is available through rolling beam allocation programmes at Diamond and ESRF. Applicants must have a PhD, and experience in recombinant expression and protein purification. Experience of crystallisation and X-ray crystallography would be an advantage. Information on our previous work in this field can be found by searching PubMed (pearl [au] and hsp90). The postholders will be responsible for expression, purification, crystallization and structural analysis of protein complexes involving Hsp90, co-chaperones and client proteins that depend on Hsp90 for their biological function. Both posts are full time and funded until 30 Sept 2011 in the first instance. Salary: £29,853 - £35,646 per annum. Informal enquiries can be made to Professor Pearl [email protected] Further Particulars and Application Forms can be found at : http://www.sussex.ac.uk/jobs/ Closing date: 10 October 2010 -------------------------------------------------------------------------------- Laurence H. Pearl PhD FMedSci FRS Professor of Structural Biology and Head of School of Life Sciences University of Sussex, Brighton, BN1 9RH, UK Phone +44-(0)1273 876 544: PA +44-(0)1273 872 699 -------------------------------------------------------------------------------- "Live Modestly and do Serious Things .. " - Dorothy Crowfoot Hodgkin --------------------------------------------------------------------------------
