Dear All, A position is available for a postdoctoral fellow to pursue structural and functional studies of proteins involved in the innate immune response of Anopheles gambiae to malaria infection. The successful candidate will be part of a new research group combining biophysical techniques such as x-ray crystallography and small-angle x-ray scattering with biochemical characterization and in vivo validation through collaborative studies. The position offers access to in-house x-ray diffraction facilities within the Chemistry Dept., numerous local core facilities, synchrotron access at NSLS and APS, and expanding opportunities for high-throughput biology at Yale's West Campus facility.
Please email a cover letter, resume and contact information for three references to richard.bax...@yale.edu, or visit http://baxterlab.sites.yale.edu for further contact information. For scientific details see the following publications: Baxter, R.H.G., et. al (2010) "A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae" PNAS 107, 16817-16822. [doi:10.1073/pnas.1010575107, PMID:20826443] Fraiture, M. et. al (2009) "Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium" Cell Host Microbe 5, 273-284. [doi:10.1016/j.chom.2009.01.005, PMID 19286136] Baxter, R.H.G. et. al (2007) "Structural basis for conserved complement factor-like function in the antimalarial protein TEP1" PNAS 104, 11615-11620. [doi:10.1073/pnas.0704967104, PMID:17606907]
