Hi All I have a dataset at 1.9A, spacegroup-P212121 (unit cell: 37.7, 39.52, 231.72, 90, 90, 90), I used MR phaser and got a structure solution with LLG= 320 (1copy/a.u) . During refinement, the R-free (50%) and R-factors (42%) never go down. I have tried refining in phenix and refmac both, but still the high R-free problem persists. At this point I'm seeking help to know the possible reasons for this high R-free.
Thanks in advance! Jyotica
