Hi, all
I am trying to build an oligomer ligand. I have obtained all the cif files
for the monomers from HIC-UP. I tried to build several monomers in using coot.
Then I modified the pdb file and stated the link in the pdb head (LINKR X ABC
1 Y ABC 2 X-Y). However, when using refmac to refine, it always
separated the monomers and broke the bond, which I could fix it back in coot
using 'real space refine zone'.
I am wondering, what is the general practice to build such oligomer ligand?
All suggestions are welcome.
thank you!
Changyi
