Dear Mohd, CCP4 contains a program SC which does the job.

sincerely

Mike Lawrence, PhD

Associate Professor and WEHI Fellow
Division of Structural Biology
Walter and Eliza Hall Institute of Medical Research
1G Royal Parade, Parkville
Victoria 3052, AUSTRALIA

Tel. 61-3-9345-2693   
Fax 61-3-9345-2686
Email: lawre...@wehi.edu.au

On 07/12/2010, at 1:54 AM, Salameh, Mohd A., Ph.D. wrote:

> Dear All,
> 
> I’m looking for a free program that I can use to measure the geometric 
> surface complementarity of protein-protein interfaces. I have created 
> inhibitor mutants that possess different binding affinities to their cognate 
> enzyme and it would be very helpful if I can quantify the shape 
> complementarity of the protein/protein interfaces. The complexes of 
> inhibitors and enzyme crystal structures have been solved at high resolution 
> (~1.4A). Sincere thanks in advance and hope to hear from you soon.
> 
> Kind regards,
> 
> Mohd Salameh
> 
> 




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