Dear Community, I have a question regarding protein model quality for introduction of point mutations which should increase solibity/stability of my protein of interest.
I plan to do homology models so that I can check the most promising amino acids. Which quality/resolution of the model do I need? Which parameters would you check (gromos, anolea), and what would you use as cut-off values? At the moment I thought, that it could be interesting to model a homologue of my protein and check the RMSDs with the crystal structure. Maybe you know some good literature, describing this? Thank you Susy
