Post Doctoral Position in structural studies of Respiratory Syncytial Virus
proteins.
A post-doctoral position in protein crystallography is available in the
group of Dr Marcel Knossow at the Laboratoire d'Enzymologie et Biochimie
Structurales (LEBS), CNRS, Gif-sur-Yvette, France. The contract will be
initially for a period of 1 year, with a net monthly salary of about 1900 €.
The Respiratory Syncytial Virus (RSV) is the major causal agent of
bronchiolitis in human. We have initiated a structural and biochemical
characterization of RSV proteins in collaboration with a group of virologists
at INRA (see Tran et al. (2009) J Virol, 83:6363-74). The project will focus on
the M2-1 protein, a transcription factor which is part of the ribonucleoprotein
complex in which it interacts with the phosphoprotein P. We aim to determine
the structure of M2-1 alone and in complex with P. The project also includes
the characterization of the interaction of M2-1 with cellular proteins we have
recently identified.
Ideally the candidate will have experience in protein crystallization and
crystallography and an interest in biochemical studies of protein-protein
interactions.
The lab is located in a multidisciplinary life sciences campus, 40
minutes by direct train from the centre of Paris. The LEBS has all the
equipment required for protein purification and characterization by biochemical
and biophysical methods. Crystallization robotics and X-ray diffraction
equipment are also available in-house or in the campus and we have regular
access to synchrotron sources (ESRF at Grenoble or the nearby SOLEIL
synchrotron).
To apply, please send a CV, a short summary of your research experience
and the names and contact information of two referees by e-mail to: Dr. Benoît
Gigant ([email protected])
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Benoit Gigant
LEBS - CNRS
Bat 34
1, avenue de la Terrasse
91198 Gif-sur-Yvette
Tel 33 1 69 82 35 01 Fax 33 1 69 82 31 29
[email protected]
Web page: http://www.lebs.cnrs-gif.fr/knossow/knossowang.html
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