The Hoelz laboratory at the California Institute of Technology seeks to recruit an outstanding postdoctoral scientist in structural biology. Our laboratory focuses on the structure-function relationships of multi-protein macromolecular assemblies. Major research themes are (1) the nuclear pore complex and evolutionarily-related vesicle coats, and (2) histone modifying enzymes and their resident multi-protein complexes.
For recent publications, see, for example, Stavropoulos et al., NSMB, 2006; Hsia et al., CELL, 2007; Melcak et al., SCIENCE, 2007; Debler et al., MOL. CELL, 2008; Nagy et al., PNAS, 2009; Hsia et al., PNAS, 2010; Hoelz et el., Annu Rev. Biochem., 2011. This position requires a recent Ph.D. degree in biochemistry/biophysics with a strong background in x-ray crystallography. The successful applicant should be a highly motivated individual with good organizational, communication, and interpersonal skills, who is able to carry out a structure determination project from protein expression to structure refinement. The laboratory is newly constructed, well-funded, and well-equipped with modern biophysical instrumentation and current crystallization robotics. Importantly, Caltech has an exceptional infrastructure for macromolecular crystallography, including 40 % access to a high intensity, completely automated, state-of-the-art crystallography beamline equipped with a PILATUS detector at the Stanford Synchrotron Radiation Lightsource (SSRL). The position is available immediately and funded for 2+ years. Depending on performance, the position can be extended for up to five years. To apply, please send your CV, a statement of research interests, and the names and contact information of at least two references to André Hoelz (ho...@caltech.edu).
