We are looking for an enthusiastic crystallographer to join our structural biology and biophysics group at the Pfizer Connecticut location. The successful candidate for this position will join Groton Structural Biology and Biophysics (SB&B), a multi-disciplinary group with well-established expertise in molecular biology, protein biochemistry, biological mass spectrometry, NMR, biophysics, crystallography & computational sciences. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to impact discovery efforts across important therapeutic areas, such as Immunology & Autoimmune Diseases, Inflammation & Remodeling, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases and Oncology.
As a Principal Scientist - Protein Crystallography, you will apply expert knowledge to determine the atomic structures of novel drug target proteins and protein-ligand complexes by protein crystallographic methods and extract novel and relevant structural insights to drive drug discovery efforts. You will need to collaborate with other scientists in our multidisciplinary SB&B teams to deliver high impact results from the laboratory, and partner with scientists across Medicinal Chemistry, Biology and other platform lines to impact project decisions. You will also use your deep knowledge in protein crystallography and other related techniques to drive the development of cutting-edge technologies and external collaborations in structural sciences. Responsibilities Primary Duties: - Determine the atomic structures of novel drug target proteins and protein-ligand complexes using protein crystallographic methods - Expert analysis of relevant data and literature to extract novel structural insights and drive drug discovery efforts. - Contribute to the design and execution of other experiments (e.g. construct design, purification, crystallization) and laboratory duties (e.g. synchrotron trips) when needed - Mentor junior scientists and contribute to vigorous experimental design and execution as well as high level of scientific engagement Qualifications Training & Education: - Doctoral degree or equivalent in Biochemistry, Chemistry or related field - Postdoctoral or industry training in Protein Crystallography - Established track record in solving novel protein structures and applying innovative methods throughout the gene-to-structure process Prior Experience: - 3-5 years of additional research experience (after postdoctoral training) in using structural information to impact drug discovery efforts, preferably in an industrial setting and through collaborative efforts Please submit your application online via the link, https://jobs.pfizer.com/psc/recruit/EMPLOYEE/EMPL/S/WEBLIB_HRS_HROI.HRS_ ISCRIPT.FieldFormula.IScript_JobBoard?PostingId=88951 With best wishes, Ravi Ravi G Kurumbail Pfizer Global Research & Development Research Fellow Mailstop: 8118W-235 Groton, CT email:[email protected]
