Some hints: Richter et al. De novo enzyme design using Rosetta3. PLoS ONE (2011) vol. 6 (5) pp. e19230
Fleishman et al. Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science (2011) vol. 332 (6031) pp. 816-21 Röthlisberger et al. Kemp elimination catalysts by computational enzyme design. Nature (2008) pp. Careful - Advertisment! http://www.mekentosj.com/papers/ Baker Seattle enzyme Should also work in Pubmed, but Papers is just a different world. [cid:[email protected].] I guess you can look at the top 100 and find something suitable to fit your bill. Jürgen P.S. if you don't have a Mac, well then forget about Papers. P.P.S. might be a reason to buy one :-) On Aug 3, 2011, at 2:57 AM, Partha Chakrabarti wrote: Hi Miguel, I second that. The problem with google is: "About 4,860,000 results (0.17 seconds)". Hence asking the wise monks.. Daniel Fernandez has been very kind to point me to some good papers. That includes a few classics from Cyrus Chothia (free from the LMB website). Thanks Daniel. Regards, Partha On Wed, Aug 3, 2011 at 11:44 AM, Miguel Ortiz Lombardia <[email protected]<mailto:[email protected]>> wrote: Le 02/08/2011 23:50, William Scott a écrit : > On Aug 2, 2011, at 2:14 AM, Partha Chakrabarti wrote: > >> Dear BBusers, >> >> Could you point me to a few classic reviews on enzyme engineering? In >> particular: >> >> a) pH, thermal & pressure stability >> b) de novo design >> c) increasing low temperature activity >> >> Regards, >> Partha > > > http://tinyurl.com/3o8ubjm > > > > William G. Scott > > Contact info: > http://chemistry.ucsc.edu/~wgscott/ > Dear Bill, While I am not the one who can give Partha an adequate answer to the posted question, I don't think that google holds always the best answer. Nor I think is more useful than asking our colleagues. It is even possible that Partha has already gone to google and found nothing convincing. In fact, I often find myself wasting time in the google mess when a proper book or a question to a colleague around (real or virtual space) would have given a faster and better answer. The 2 cts of a non-believer, in the google god also. Best, -- Miguel Architecture et Fonction des Macromolécules Biologiques (UMR6098) CNRS, Universités d'Aix-Marseille I & II Case 932, 163 Avenue de Luminy, 13288 Marseille cedex 9, France Tel: +33(0) 491 82 55 93 Fax: +33(0) 491 26 67 20 mailto:[email protected]<mailto:[email protected]> http://www.afmb.univ-mrs.fr/Miguel-Ortiz-Lombardia -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean. ...................... Jürgen Bosch Johns Hopkins Bloomberg School of Public Health Department of Biochemistry & Molecular Biology Johns Hopkins Malaria Research Institute 615 North Wolfe Street, W8708 Baltimore, MD 21205 Phone: +1-410-614-4742 Lab: +1-410-614-4894 Fax: +1-410-955-3655 http://web.mac.com/bosch_lab/
<<inline: Screen shot 2011-08-03 at 7.21.40 AM.png>>
