We have structures of two states of a large multi-domain protein in which domain movements of up to 30 degrees are observed. Is there a programme available which attempts to determine rigid-body units and hinge regions in an 'unbiased' way?
thanks for your suggestions,
Stephen Cusack

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Dr. Stephen Cusack,     
Head of Grenoble Outstation of EMBL
Group leader in structural biology of protein-RNA complexes and viral proteins
Joint appointment in EMBL Genome Biology Programme
Director of CNRS-UJF-EMBL International Unit (UMI 3265) for Virus Host Cell 
Interactions (UVHCI)
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