What do you consider good ? r.m.s.d of 2.5 Å ? fatal for drug design. On Oct 18, 2011, at 12:19 PM, Enrico Stura wrote:
Dear Peter, How many crystallographers does it take to transform bad data into good data? None, you need a modeller. Only a modeller can give you a structure with perfect geometry. Data just introduces experimental errors into what would otherwise be a perfect structure. If you have good data do you need crystallographers? No just the right programs. Which brings us back to the hypothetical question of why do we care ? I mean more precisely the question each of us is trying to answer in their own research program. Crystallography is a high-end tool, not quite as simple as a western blot or ELISA but in the end it's just a tool to answer some critical questions. Jürgen ...................... Jürgen Bosch Johns Hopkins University Bloomberg School of Public Health Department of Biochemistry & Molecular Biology Johns Hopkins Malaria Research Institute 615 North Wolfe Street, W8708 Baltimore, MD 21205 Office: +1-410-614-4742 Lab: +1-410-614-4894 Fax: +1-410-955-2926 http://web.mac.com/bosch_lab/
