In theory, no: sub-angstrom resolution can be obtained for any and all proteins, including membrane proteins, and for large complexes. In reality, it becomes technically very difficult to achieve; you would need ever-colder temperatures and ever-stronger irradiation sources.
P.S. In theory, the only limit to describing the location of the atoms would be described by the heisenberg uncertainty principle. On Mon, Jan 9, 2012 at 1:15 PM, Theresa H. Hsu <[email protected]> wrote: > Dear crystallographers > > A theoretical question - can sub-angstrom resolution structures only be > obtained for a limited set of proteins? Is it impossible to achieve for > membrane proteins and large complexes? > > Theresa >
