Dear CCP4bb readers, a postdoctoral position and a scientific officer / higher scientific officer position are available at The Institute of Cancer Research (ICR, Chelsea, London, UK), to undertakes crystallographic, single particle electron microscopy analysis and biochemical analysis of large eukaryotic transcriptional complexes. We are particularly interested in studying macromolecular complexes that are involved in cancer development and several projects (which require different skills) are available.
The Division of Structural Biology of the ICR has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants for the postdoctoral position should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of protein purification for structural biology analysis. Experience in recombinant protein production and purification as well as protein crystallography and/or single particle electron microscopy is essential. Experience in the biochemistry of multi-subunit protein complexes, yeast genetics or protein production in insect cells (MultiBac) would be an advantage. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £27,536 to £33,852 p.a. inclusive (based on previous post-doctoral experience). For further particulars and details of how to apply, please refer to this vacancy on our online application portal: Ref n. 1228522 Applicants for the scientific officer / higher scientific officer should possess a BSc. (or equivalent) in molecular biology or cell biology with sound knowledge of cloning techniques. Experience in molecular cloning and protein expression is essential. Experience in yeast genetics and/or or protein production in insect cells (MultiBac) would be an advantage. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £23,000 to £29,545 p.a. inclusive dependant on skills and experience. In addition to annual performance related pay awards we offer a generous leave entitlement of 25 days annual leave per annum which rises to a maximum of 30 days per annum related to length of service, as well as 8 bank/public holidays and 3 additional ICR-set privilege days per annum. For further particulars and details of how to apply, please refer to this vacancy on our online application portal: Ref n. 1228533 Closing date: 8th February 2012 Please direct informal inquiries to Dr. Alessandro Vannini at [email protected] Please DO NOT send your application to Dr. Alessandro Vannini; CVs must be submitted in line with the instructions above.
