DEADLINE APPROACHING! Our group has been involved in structural studies of several novel enzymes interesting from the point of view of biotechnologies,
such as Laccase from *S. coeliocolor, *beta-galactosidase from Arthrobacter (660 kDa) or recently plant metal-dependent bifunctional nuclease or bacterial organophosphate anhydrolases for removal of toxic warfare agents. To continue studies in this area and apply mostly structure-driven analysis on further targets we are still accepting applications for a postdoc position. The Institute of Macromolecular Chemistry of the Academy of Sciences (IMC) in Prague, Czech Republic searches for highly motivated young researchers for a full time research postdoctoral position in the area of *Structural Analysis of Biomacromolecules.* The position is offered within the Department of Structural Analysis of Biomacromolecules (http://www.imc.cas.cz/en/umch/o_struanal.html) where the central technique is x-ray diffraction analysis of mostly protein structures. *Topic A: Structure and function of enzymes for biotechnologies* *Structure-function studies of enzymes with biotechnological applications.* The work will be focused on defining macromolecular targets, protein production and purification in collaboration with a partner, crystallization, X-ray diffraction, determination and interpretation of structure, design of mutations and complementary biophysical techniques, including measurements of reaction kinetics, inhibition and complex formation. The successful applicant will be also involved in ligand selection/design and studies of complexes of such compounds with the target macromolecules. The applicant has received PhD or equivalent in one of the following fields: biophysics, physics, biochemistry, chemistry, molecular biology or closely related. Required experience and skills: protein crystallography, biochemistry, reaction kinetics, inhibition. Practical experience with protein-ligand interaction studies (ITC, SPR, etc.) and with enzyme modification/optimization is welcome. * * The applicant has received PhD degree after May 28, 2008. *Contract type: * Full time, fixed term, 3 years, starting 1st July 2012, EU funded via the Czech Ministry of Education. You can contact me on this e-mail address or send your full application according to instructions available here: http://www.imc.cas.cz/en/umch/aktuality.htm?id=97 The deadline for full applications is February 29! Jan Dohnalek IMC Prague -- Jan Dohnalek, Ph.D Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic Heyrovskeho nam. 2 16206 Praha 6 Czech Republic Tel: +420 296 809 390 Fax: +420 296 809 410
