Post-doctoral and PhD positions available in the group of Titia K. Sixma, 
Netherlands Cancer Institute, Amsterdam

We are looking for motivated enthousiastic researchers with strong experience 
in X-ray crystallography and protein biochemistry. Projects are focussing on 
ubiquitin conjugation processes in DNA regulation, where we study the roles of 
E3 ligases and deubiquitinating enzymes. Aims are to reconstitute larger 
complexes in vitro and study structural and functional aspects of the basic 
enzymatic activities and correlate these to cellular function.

The NKI is well-established as a center of excellence for cancer research, with 
strong genetics, cell biology and structural biology. The institute is highly 
interactive and is well set up with strong core facilities. For structural 
biology we share equipment between the Sixma and Perrakis labs and the protein 
facility . Setup is excellent for biochemistry, biophysics (ITC, Malls, stopped 
flow, SPR, fluorescence etc) and X-ray crystallography.

Amsterdam is a very livable city with many cultural amenities. The institute is 
located within a 20 minute tram or bicycle ride from the center of Amsterdam 
and within 20 minutes from Schiphol airport by car, bus or bicycle.

Titia K. Sixma
Division of Biochemistry
Nederlands Kanker Instituut
Plesmanlaan 121
1066 CX Amsterdam

E-mail: [email protected]
Tel: +31-20-5121959
Website: http://xtal.nki.nl

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