Dear CCP4 Community,

We are looking for a motivated Scientific Officer / Higher Scientific Officer 
to join our exciting research programme on the regulation and functions of 
ADP-ribosyltransferases. Please see the job description and instructions on how 
to apply below.

Best wishes,
Sebastian



Scientific Officer/Higher Scientific Officer Position at ICR, London, UK

Job title: Scientific Officer/Higher Scientific Officer
Closing date of vacancy: 20 July 2012
Starting date of position: mid-October / early November 2012
Division: Structural Biology & Cancer Biology
Team: Guettler Group
Type of Contract: fixed term
Length of contract: 3 years from mid-October 2012
Salary range: £23,000 to £29,545 p.a. inclusive (depending on skills and 
experience)
Work location: London, UK


In the Divisions of Structural and Cancer Biology, our new team led by Dr. 
Sebastian Guettler has a vacancy for a Scientific Officer or early-career 
Higher Scientific Officer. The objective of this post will be to provide 
support within Dr. Guettler's laboratory for research into the structure and 
function of proteins. The post holder will work as a member of a 
multidisciplinary team investigating the functions and regulation of 
ADP-ribosyltransferases. The work will involve the production and purification 
of proteins and protein complexes, their characterisation, crystallisation and 
functional analysis.

The work in the Divisions of Structural and Cancer Biology is centred on 
cellular processes that give rise to cancer and on approaches for anti-cancer 
therapy. Research in the Division of Structural Biology focuses on the 
structural and biochemical characterisation of proteins and complexes relevant 
to cancer and employs techniques that include X-ray crystallography, electron 
microscopy and a variety of biochemical/biophysical methods. Research 
activities in the Division of Cancer Biology include mammalian genetics, 
imaging and proteomics.

Applicants should minimally possess a BSc. (or equivalent) in molecular 
biology, biochemistry or cell biology. Experience in molecular cloning, 
recombinant protein expression in E. coli and large-scale, 
crystallisation-grade protein purification is essential. Experience with 
protein production in insect cells (MultiBac) and mammalian cell culture would 
be an advantage.

Appointment will be on a Fixed Term Contract for 3 years in the first instance 
with a starting salary in the range of £23,000 to £29,545 p.a. inclusive 
dependent on skills and experience.  The earliest expected start date will be 
mid-October 2012.

In addition to pay awards related to annual performance, we offer a generous 
leave entitlement of 25 days of leave per annum which rises to a maximum of 30 
days per annum, related to length of service, as well as 8 bank/public holidays 
and 3 additional ICR-set privilege days per annum.

For further details and instructions on how to apply, please refer to our 
online vacancy and recruitment site at http://www.icr.ac.uk/jobsearch, quoting 
job reference number 1260528 for this position.

While applications need to be placed via our online system, informal inquiries 
can be sent to Dr. Sebastian Guettler at [email protected].

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

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