A position is available in the Centre for Translational Therapeutics (CTT) within the College of Medicine, Biological Sciences and Psychology for a talented postdoctoral structural biologist to work on a collaborative in-house structural biology projects, with an emphasis on structure-based drug discovery and development. The CTT is headed by Prof. Andrew Tobin and aims to facilitate early phase drug discovery within the College. The scientist will be based in the Department of Biochemistry and will work alongside the groups of Prof. Mark Carr (NMR spectroscopy) and Dr Richard Bayliss (X-ray crystallography), who have strong track records in structure-based drug discovery. The scientist will determine the structures of proteins that are targeted by CTT and characterise their interactions with candidate compounds. The proposed work will involve close interactions with other postdoctoral scientists within the CTT, research groups across the College and medicinal chemistry collaborators. The CTT and Department of Biochemistry are superbly equipped for inhibitor discovery using mobility-shift, label-free and thermal shift assays, as well as for all aspects of NMR spectroscopy and X-ray crystallography based structural biology, with excellent supporting facilities for recombinant protein expression and purification.
The successful postdoctoral research fellow will have a proven track record in structural biology, with significant experience in X-ray crystallography and/or NMR-based approaches. A willingness to apply either approach to solve protein structures would be desirable. A strong interest in knowledge-based drug discovery is essential. The ability and willingness to travel to meetings with collaborators and to use off-campus research facilities is essential. Good communication and presentation skills are also a pre-requisite. Salary Grade 8 - £39,257 to £44,166 per annum. Available immediately for an initial period of 1 year, with the expectation of extension for a further 2 years Informal enquiries may be made to Dr Richard Bayliss, Tel +44 (0)116 229 7100, E.mail [email protected]; or Prof. Mark Carr, Tel: +44 (0)116 229 7075, E.mail: [email protected]; or Prof. Andrew Tobin, Tel: +44 (0)116 252 2935, Email: [email protected] Applications must be made through the University jobs page, on which further details are available (http://www2.le.ac.uk/offices/jobs/opportunities/jobsearch - reference MBP00666) The closing date for this post is midnight on 19th August 2012. ============================= Dr Richard Bayliss, Reader in Structural Biology Department of Biochemistry Henry Wellcome Building University of Leicester Lancaster Road, Leicester LE1 9HN Tel: 0116 2297100 Web: http://www2.le.ac.uk/departments/biochemistry/staff/richard-bayliss/research Elite Without Being Elitist Times Higher Awards Winner 2007, 2008, 2009, 2010, 2011 Follow us on Twitter http://twitter.com/uniofleicester
