Dear All,
We have a structure at its final stages of refinement (R~0.215,
Rfree~0.235) whose 1.9A 2mFo-DFc and mFo-DFc maps are a pleasure to have
and to share, with the notable exception of a 'feature' present on one of
the prolines:
https://dl.dropbox.com/u/11392126/alpha-Me-proline.jpg
[the positive (green) contour of the difference map stands at a hefty 5
sigma above mean]. It looks as if this is an alpha-Methyl-L-Proline but my
attempts to locate natural occurences of this modification in proteins
have all failed. Any ideas or suggestions or pointers ?
All the best,
Nicholas
--
Nicholas M. Glykos, Department of Molecular Biology
and Genetics, Democritus University of Thrace, University Campus,
Dragana, 68100 Alexandroupolis, Greece, Tel/Fax (office) +302551030620,
Ext.77620, Tel (lab) +302551030615, http://utopia.duth.gr/~glykos/
