Dear all,
Is there any convention on the numbering of residues in a fusion protein?
I have a structure of two domains fused together but would like to keep
the biological numbering intact.
1st domain: residue 200-300 (protein A).
2nd domain: residue 170-350 (protein B).
The fusion is between A300 and B170
Is it OK to label them chain A and B and create a LINK between the two
(thus keeping the biological residue number intact).
Or do I have to start the 2nd domain with residue number 301 (and loose
all biological information).
Many thanks,
Meindert
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Meindert H. Lamers
Medical Research Council
Laboratory of Molecular Biology
Hills Road,
Cambridge, CB2 0QH
United Kingdom
tel +44 (0)1223 402401
fax +44 (0)1223 213556
web: http://www2.mrc-lmb.cam.ac.uk/groups/mlamers/
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