Reference Number: LS0313 Job Title: Postdoctoral Research ASsociate
College: College of Life Sciences School: Life Sciences Research Division: Biological Chemistry and Drug Discovery Grade: *Grade 7 (£29,541 - £36,298)** * Job Category: Research Closing Date: 1 May 2013 A postdoctoral position is available immediately in the new laboratory of Dr. Alessio Ciulli (http://www.lifesci.dundee.ac.uk/people/alessio-ciulli) to work on a project funded by the BBSRC. We are looking for an enthusiastic and motivated post-doctoral scientist to join a team of researchers broadly interested in Chemical & Structural Biology of Protein-Protein Interactions. You will investigate structure-function relationships within a family of human proteins containing bromodomains. We are interested in unveiling the molecular basis underpinning selectivity of small-molecule probes targeting such domain, which read histone post-translational modifications and are found in histone acetyl transferases and other chromatin-associated proteins involved in the epigenetic regulation of gene expression. The ultimate goal of the research is to aid elucidation of the roles of individual bromodomains in human biology and disease. The project will involve protein engineering, purification and crystallization, structure solution by X-ray crystallography, and structural and biophysical techniques to study protein-ligand interactions and determine structure-activity relationships. It is in collaboration with Prof. Stefan Knapp at the Structural Genomics Consortium of Oxford University (see Molecular Biosystems (2011) 7, 2899-908). *The ideal candidate will posses or be able to demonstrate the following: * • A PhD with outstanding academic track record and at least one first authored publication in an internationally recognized peer-reviewed journal (published or in press) • Enthusiasm for Science • Independence • Strong background in protein purification and crystallography, X-ray data collection (in-house and at synchrotrons), structure solution and model refinement • Experience with biophysical techniques studying protein-ligand interactions; a strong interest in fragment-based / structure-based drug design and/or protein NMR would be advantageous • Capable of working in a team, but able to plan and work independently • Excellent communication skills and knowledge of the English language are essential *Ciulli lab / College of Life Sciences / Division of Biological Chemistry & Drug Discovery:* You will be working in a highly international research group that operates across the disciplines of chemical & structural biology, molecular biophysics, medicinal chemistry and drug design. More information on our group can be found on http://www-ciulli.ch.cam.ac.uk/index.htm. Training, as required, will be provided in a well-equipped, well-funded and supportive environment enabling the successful candidate to extend skills and expertise. The College of Life Sciences is equipped with state-of-the-art facilities to conduct cutting-edge research in all aspects of modern chemical biology, structural biology and molecular biophysics. The Division of Biological Chemistry & Drug Discovery (BCDD) aims to discover chemical solutions to biological problems through excellence in basic and applied multidisciplinary research. For further information about the Division of Biological Chemistry & Drug Discovery, please consult our website: http://www.lifesci.dundee.ac.uk/research/bcdd. This post is available until December 2014. Informal enquiries may be made to Dr. Alessio Ciulli, e-mail: [email protected]. *How to apply:* * * To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0313. The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. * * *The University of Dundee is a Scottish Registered Charity, No. SC015096.*
