Postdoctoral Research Assistant in Structural & Chemical Biology: Structure-function and druggability of epigenetics PPIs
College of Life Sciences, University of Dundee - Biological Chemistry and Drug Discovery Unit Full time, fixed term until January 2015 in the first instance Salary range: Grade 7 (£29,541 - £36,298) Closing date for applications: Monday, October 21, 2013 - 00:00 Description A postdoctoral position is available immediately in the laboratory of Dr. Alessio Ciulli to work on a project funded by the BBSRC. We are looking for an enthusiastic and motivated post-doctoral scientist to join a team of researchers broadly interested in Chemical & Structural Biology of Protein-Protein Interactions (PPIs). In this project we aim to unveil the molecular basis underpinning selectivity of small-molecule probes targeting epigenetic domains which read histone post-translational modifications. You will investigate structure-function relationships within an epigenetic protein family containing bromodomains that are found in histone acetyl transferases and other chromatin-associated protein complexes involved in the regulation of gene expression. The ultimate goal of the research is to aid elucidation of the roles of individual bromodomains in human biology and disease. The project will combine protein expression, purification and crystallization, structure solution by X-ray crystallography, and structural and biophysical techniques to study protein-ligand interactions and determine structure-activity relationships. It is in collaboration with the Oxford Structural Genomics Consortium. The ideal candidate will posses or be able to demonstrate the following: • A PhD with outstanding academic track record and at least one first authored publication in an internationally recognized peer-reviewed journal (published or in press) • Strong background in protein purification and crystallography, X-ray data collection (in-house and at synchrotrons), structure solution and model refinement • Experience with biophysical techniques studying protein-ligand interactions; a strong interest in fragment-based / structure-based drug design and experience with NMR spectroscopy or other structural biology techniques would be advantageous • Enthusiasm for Science • Independence • Capable of working in a team, but able to plan and work independently • Excellent written, oral and interpersonal communication skills and knowledge of the English language are essential Informal enquiries may be made to Dr. Alessio Ciulli, e-mail: [email protected]. For more information on how to apply please visit here. ------------------------------------------------------------------------------ Dr Alessio Ciulli Reader in Chemical & Structural Biology BBSRC David Phillips Fellow College of Life Sciences, University of Dundee Division of Biological Chemistry and Drug Discovery James Black Centre Dow Street, Dundee DD1 5EH UK Phone: +44 (0)1382 386230 Fax: +44 (0)1382 386373 http://www.lifesci.dundee.ac.uk/people/alessio-ciulli http://www.lifesci.dundee.ac.uk/groups/alessio-ciulli ------------------------------------------------------------------------------
